Breast Cancer Cell Lines
Most cell lines were established in late 1970s. Breast adenocarcinoma homo sapiens 37 years caucasian crl 7245 hs 343 t mammary gland.
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Ever since the establishment of the first breast cancer cell line bt 20 in 1958 relatively few cell lines have been obtained due to technical difficulties in extracting viable tumor cells from the surrounding stroma 12 13 and the bottleneck of long term propagation during cultivation 12 14.
Breast cancer cell lines. Based on the characteristics of the cell line and experimental need cell lines may be used in one or more applications. Choosing the right cell line for breast cancer research abstract. Cancer cell lines are the foundation for cancer research.
Ecacc breast cancer cell lines. They have been extensively used in countless studies because they are easy to use and cost effective. Name tissue cell type disease oganism age ethnicity genes expressed crl 7227 hs 281 t mammary gland.
Breast adenocarcinoma homo sapiens 47 years caucasian crl 7253 hs 362 t. This is a list of major breast cancer cell lines that are primarily used in breast cancer research. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases.
This type of cancer forms in the lining of a milk duct within your breast. In general the recurrent genomic and transcriptional characteristics of 51 breast cancer cell lines mirror those of 145 primary breast tumors although some significant differences are documented. Gene expression profiling has contributed significantly.
Mcf 7 is the acronym of michigan cancer foundation 7 referring to the institute in detroit where the cell line was established in 1973 by herbert soule and co workers. The michigan cancer foundation is now known as the barbara ann karmanos cancer institute. The cell lines that comprise the system also exhibit the substantial genomic transcriptional and biological heterogeneity found in primary tumors.
In microarray profiling the mda mb 231 cell genome clusters with the basal subtype of breast cancer. The mda mb 231 cell line isolated at m d anderson from a pleural effusion of a patient with invasive ductal carcinoma is commonly used to model late stage breast cancer. Ductal carcinoma is the most common type of breast cancer.
Breast cancer is a complex and heterogeneous disease. The ducts carry breast milk from the lobules where it s made to the nipple. Mcf 7is a breast cancer cell line isolated in 1970 from a 69 year old caucasian woman.
Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. Breast cancer and normal cell lines atcc no. This cell line is er pr and e cadherin negative and expresses mutated p53.
Human breast cancer cell lines bcc selected for resistance to antineoplastic agents are a valuable research tool for studying the mechanisms associated with the development of drug resistance the major cause for chemotherapy failure in breast cancer patients. The first human cell line was established in a baltimore laboratory over 50 years ago by george gey 1.
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