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Elion 1918 1999 discovered 6 mercaptopurine thioguanine jbc 1951 and azathioprine cancer res. 5 this may be mediated through rac1 s action on mitogen activated protein kinase nf kappab. Interruption Of Autoimmunity For Thyroid Eye Disease B Cell And T Azathioprine 6 mercaptopurine 6 mercaptopur…

It is used in rheumatoid arthritis granulomatosis with polyangiitis crohn s disease ulcerative colitis systemic lupus erythematosus and in kidney transplants to prevent rejection. One metabolic pathway is through its conversion to 6 mercaptopurine the active metabolite of 6 mercaptopurine being 6 …