Blood Gas Partition Coefficient
Ether on the other hand has a blood gas partition coefficient of 12 l thus it dissolves very well in blood. Nitrous oxide no has a blood gas partition coefficient of 0 47 l thus it is dissolves poorly in blood.
It is the partial pressure of the agent in the blood and hence the brain that gives rise to anaesthesia.
Blood gas partition coefficient. It describes the partition of an agent between a gaseous phase such as alveolar air and the blood. A partition coefficient is the ratio of the concentrations of a compound in one solvent to the concentration in another solvent at equilibrium. The greater the blood gas partition coefficient the greater the solubility in blood.
The blood gas coefficient is the ratio of the amount of anaesthetic in blood and gas when the two phases are of equal volume and pressure and in equilibrium at 37 degrees c. Blood gas partition coefficient also known as ostwald coefficient for blood gas 1 is a term used in pharmacologyto describe the solubility of inhaled general anestheticsin blood 2 according to henry s law the ratio of the concentration in blood to the concentration in gas that is in contact with that blood when the partial pressurein both compartments is equal is nearly constant at sufficiently low concentrations. The media can be gases such as air liquids such as water or olive oil or complex mixtures such as blood or other tissues.
The blood gas partition coefficient is also known as ostwald coefficient for blood gas. It should also be noted that gases with high blood gas coefficients have a slower onset of action higher solubility in blood and slow equilibrium with the brain. The blood gas partition coefficient describes how the gas will partition itself between the two phases after equilibrium has been reached.
The blood gas partition coefficient is an important determinant of the speed of anesthetic induction and recovery. Partition coefficients are defined as the concentration ratio of a chemical between two media at equilibrium see also chapter 1 04. The coefficients of most clinical relevance are the blood gas and oil gas partition coefficients.
Anesthetics that are highly soluble in the brain have high blood gas partition coefficients.
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