Niacin Mechanism Of Action Cholesterol
In doses as high as 1 500 2 000mg is proven to reduce ldl bad cholesterol. High density lipoprotein cholesterol hdl c has been shown in epidemiologic studies to be associated with cardiovascular cv risk and thus significant efforts have been focused on hdl c modulation.
Mechanism Of Action Of Niacin Sciencedirect
The mechanism of action of niacin to raise hdl is by decreasing the fractional catabolic rate of hdl apo ai without affecting the synthetic rates.
Niacin mechanism of action cholesterol. Enhanced myocardial preservation by nicotinic acid an antilipolytic compound. Datta s das dk engelman rm et al. Niacin can raise hdl cholesterol by more than 30 percent.
Niacin the mo. There s currently some debate about the exact role hdl plays in the body and in the development of heart disease. To present an integrated overview of the mechanism of action of niacin the review is divided into 4 sections covering 1 the basic mechanisms of niacin to decrease lipids and apo b containing lipoproteins eg ldl vldl 2 mechanisms of niacin to increase apo a i and hdl 3 novel non lipid related action of niacin to influence vascular inflammatory and oxidative processes involved in atherogenesis and 4 the mechanism of action of niacin to induce an adverse flush response.
The two forms of niacin can serve as probes in studying lipoprotein interrelationships. Multiple pharmaceutical agents have been developed with the goal of increasing hdl c. Previous article in issue next article in issue.
Recent studies indicate that niacin increases vascular endothelial. Additionally niacin selectively increases the plasma levels of lp ai hdl subfraction without apo aii a cardioprotective subfraction of hdl in patients with low hdl. The mechanism whereby niacin lowers triglyceride and raises hdl appears to differ from the mechanism of ldl cholesterol lowering as do the mechanisms increasing hdl 2 and hdl 3 cholesterol.
But hdl has generally been thought to pick up excess bad cholesterol in your blood and take it to your liver for disposal which is why hdl is dubbed the good cholesterol. Initial data suggest that niacin by inhibiting the hepatocyte surface expression of beta chain adenosine triphosphate synthase a recently reported hdl apo a i holoparticle receptor inhibits the removal of hdl apo a i. Niacin in much higher doses than those recommended as daily dietary allowance is a potent agent against dyslipidaemia.
Although decreased free fatty acid mobilization from adipose tissue via the g protein coupled receptor 109a niacin receptor has been a widely suggested mechanism of niacin to decrease tgs physiologically and clinically this pathway may be only a minor factor in explaining the lipid effects of niacin.
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