Triple Negative Breast Cancer Cell Lines

They have been extensively used in countless studies because they are easy to use and cost effective. The front door may have three kinds of locks called receptors.

Jci Identification Of Human Triple Negative Breast Cancer

Triple negative breast cancer tnbc is a subtype of highly malignant breast cancer with poor prognosis.

Triple negative breast cancer cell lines. Learn more about triple negative breast cancer. In general these studies have shown that the luminal basal her2 and claudin low clusters identified in breast tumours can easily be distinguished in breast cancer cell lines table 1 13 22. Triple negative breast cancer cell lines.

The approach examines not only dna mutations but also gene and protein expression levels. The term triple negative breast cancer refers to the fact that the cancer cells don t have estrogen or progesterone receptors and also don t make too much of the protein called her2. If you ve been diagnosed with breast cancer you may learn that the breast cancer cells test negative for estrogen and progesterone receptors and her2.

About 10 20 of breast cancers are triple negative. We analysed two cell lines. Think of cancer cells as a house.

Ref lehmann bd et al. It is the most heterogeneous among all subtypes and referred to as basal a and basal b cell lines in many literatures. A panel of 17 triple negative breast tumor cell lines sharing a mesenchymal like or luminal morphology.

The team s method for identifying these biomarkers of drug response in triple negative breast cancer cell lines was recently published in the journal breast cancer research and treatment. Triple negative breast cancer is a kind of breast cancer that does not have any of the receptors that are commonly found in breast cancer. Testing negative for all three is often called triple negative.

One is for the female hormone progesterone. Tnbc is not amenable to endocrine therapy and often exhibit resistance to current chemotherapeutic agents therefore further understanding of the biological properties of these cancer cells and development of effective therapeutic approaches are urgently needed. Application of sophisticated transcriptional profiling to breast cancer cell lines using various platforms has gone some way to address these issues.

See j clinical inv 2011 121 7 2750 2767 for more information. The cells test negative on all 3 tests. One is for the female hormone estrogen.

In addition investigations of poly adp ribose polymerase inhibitors are underway to target triple negative breast cancers 3. Identification of human triple negative breast cancer subtypes and preclinical models for selection of targeted therapies. Cancer cell lines are the foundation for cancer research.

Triple negative breast cancer tnbc accounts for about 10 15 of all breast cancers. Herein we investigated the effects of salinomycin on the viability and migration of triple negative breast cancer cells. What is triple negative breast cancer.

Triple negative cell lines as represented by the name are featured by low or no expression of all three markers i e er pr her2. I triple negative mda mb 231 breast cancer cells and ii a cytokeratin 18 transfected re differentiated subclone of the mda mb 231 cell line.

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