Thin Basement Membrane Disease
A collection of disease information resources and questions answered by our genetic and rare diseases information specialists for thin basement membrane nephropathy skip to main content u s. Thin basement membrane disease symptoms and signs.
Cohen gerald appel in chronic renal disease second.
Thin basement membrane disease. Most patients with tbm disease maintain normal kidney function throughout their lives. Thin basement membrane disease tbmd is an inherited disorder that mainly affects the glomeruli which are tiny tufts of capillaries small blood vessels in the kidneys that filter wastes from the blood. Thin basement membrane disease non neoplastic kidney.
Most patients are asymptomatic and are incidentally noted to have microscopic hematuria on routine. Thin basement membrane disease affects a heterogeneous group of people. The history and presentation are helpful in this regard.
Image provided by agnes fogo md and the american journal of kidney disease s atlas of renal pathology see. The only abnormal finding in this disease is a thinning of the basement membrane of the glomeruli filters in the kidneys. Approach to the patient with chronic glomerular disease.
In alport syndrome there is often a family history of kidney failure which may be associated with hearing impairment. In iga nephropathy episodes of frank hematuria are more common and a family history is less common. Tbm disease also known as benign familial hematuria and thin basement membrane nephropathy is along with iga nephropathy the most common cause of blood in the urine without any other symptoms.
Department of health human services. It is a rare disorder that has been diagnosed in less than 1 percent of the population.
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