Azathioprine Mechanism Of Action

It is used in rheumatoid arthritis granulomatosis with polyangiitis crohn s disease ulcerative colitis systemic lupus erythematosus and in kidney transplants to prevent rejection. One metabolic pathway is through its conversion to 6 mercaptopurine the active metabolite of 6 mercaptopurine being 6 thioinosinic acid.

Azathioprine Wikipedia

One metabolic pathway is through its conversion to mercaptopurine the active metabolite of mercaptopurine being 6 thioinosinic acid.

Azathioprine mechanism of action. Azathioprine may cause a serious brain infection that can lead to disability or death. Common side effects include bone marrow suppression and vomiting. It is used to treat patients who have undergone kidney transplantation and for diseases in which modifying the activity of the immune system is important.

What is azathioprine and how does it work mechanism of action. Azathioprine is an immunosuppressant that is a drug that is used to suppress the immune system. The drug is a purine analog and the accepted mechanism of action is at the level of dna 1 3.

Azathioprine is metabolized in the liver before becoming active. 6 thioguanine triphosphate a metabolite of azathioprine modulates activation of rac1 when costimulated with cd28 inducing t cell apoptosis. Azathioprine aza sold under the brand name imuran among others is an immunosuppressive medication.

It is taken by mouth or injected into a vein. Azathioprine and 6 mercaptopurine are thiopurines and azathioprine is an imidazolyl derivative of 6 mercaptopurine. Swelling of your face lips tongue or throat.

Azathioprine s mechanism of action is not entirely understood but it may be related to inhibition of purine synthesis along with inhibition of b and t cells. Azathioprine and mercaptopurine are thiopurines and azathioprine is an imidazolyl derivative of mercaptopurine. Get emergency medical help if you have signs of an allergic reaction.

Azathioprine is metabolized in the liver before becoming active. Both in vitro and in vivo azathioprine is metabolized to 6 mp through reduction by glutathione and other sulphydryl containing compounds and then enzymatically converted into 6 thiouric acid 6 methyl mp and 6 thioguanine 6 tg 1 3.

Optimizing 6 Mercaptopurine And Azathioprine Therapy In The