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It is used in rheumatoid arthritis granulomatosis with polyangiitis crohn s disease ulcerative colitis systemic lupus erythematosus and in kidney transplants to prevent rejection. One metabolic pathway is through its conversion to 6 mercaptopurine the active metabolite of 6 mercaptopurine being 6 …

1 5 2 5 mg kg po once daily. Azathioprine decreases the metabolism of purines and may inhibit dna and rna synthesis as well. Inflammatory Bowel Disease Nejm Ulcerative colitis off label maintenance remission or reduction of steroid. Azathioprine mechanism of action ibd . 100 2305 pmol mg dna cu…