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Elion 1918 1999 discovered 6 mercaptopurine thioguanine jbc 1951 and azathioprine cancer res. 5 this may be mediated through rac1 s action on mitogen activated protein kinase nf kappab. Interruption Of Autoimmunity For Thyroid Eye Disease B Cell And T Azathioprine 6 mercaptopurine 6 mercaptopur…

It is used in rheumatoid arthritis granulomatosis with polyangiitis crohn s disease ulcerative colitis systemic lupus erythematosus and in kidney transplants to prevent rejection. One metabolic pathway is through its conversion to 6 mercaptopurine the active metabolite of 6 mercaptopurine being 6 …

1 5 2 5 mg kg po once daily. Azathioprine decreases the metabolism of purines and may inhibit dna and rna synthesis as well. Inflammatory Bowel Disease Nejm Ulcerative colitis off label maintenance remission or reduction of steroid. Azathioprine mechanism of action ibd . 100 2305 pmol mg dna cu…

Inhibition of the cell cycle azathioprine cyclophosphamide methotrexate and mycophenolate mofetil. Azathioprine also may integrate into nucleic acids resulting in chromosome breakage nucleic acid malfunction or the synthesis of faulty proteins. Myasthenia Gravis Neurology Internal Medicine Corre…